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RSH Data & Documents "Health Effects Title Page: Front matter |
Dedicated to the victims of the atomic bombings; the late Dr Alexander Hollaender, master of the way of science; Masayuki Hukuhara, my teacher in the way of Zen; and my wife Kyoko. HEALTH EFFECTS |
Front page
color photo Immunochemical staining of p53 protein in colorectal tumor specimens. A, B:
cultured colorectal tumor cells with p53 point mutations; A, after staining by the normal
method and B, after staining with antibody to p53 protein. A p53 oncogenic point mutation
produces a p53 oncoprotein with improved stability, giving rise to a large amount of p53
protein which accumulates in the nuclei of tumor cells; too little normal p53 protein is
accumulated to be detected by the staining method used. C: adenoma with moderate
dysplasia; D: adenoma with severe dysplasia, with a p53 point mutation; E and F:
intramucosal carcinoma and invasive carcinoma, both with p53 point mutations. Cells in
which the nucleus is stained with p53-protein antibody were not seen in C, were rare in D
(arrow) and occurred ubiquitously in E and F (courtesy of Michiko Miyaki) |
RSH > Documents >"Health Effects of Low-level Radiation" Review> Title Page: Front matter
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