|
Radiation,
Science, and Health
Author Index
to Papers and Documents
Dr. Shu-Zheng
Liu
liushzh@jlu.edu.cn
drliusz@yahoo.com
[bio]
Science Papers
Technical Articles
Conference Papers
Presentations
Correspondence |
Science
Papers
Cellular and
molecular changes induced by low versus high dose radiation
MH Radiobiology Research Unit, Norman Bethune University of Medical
Sciences, Changchun, China, 2000.
Abstract:
"..When one goes down to the lower dose range, especially with doses below
0.2 Gy, changes of many biological parameters in the opposite direction to those observed
with doses higher than 0.5 Gy are often documented, thus resulting in a U- or
J-shaped or an inverted U- or J-shaped curve. In the present paper ... data from the
author’s laboratory demonstrate the difference in nature of effects induced by low
versus high dose X-rays at molecular and cellular levels, as well as their implications in
the intact organism. A hypothetical dose-effect model is suggested to summarize the
observations."
Abstracts of research and review papers 1995-2000
by Shu-Zheng Liu and co-workers
MH
Radiobiology Research Unit, Norman Bethune University of Medical Sciences,
Changchun, China, 2000.
85
ABSTRACTS provide consistent research
results and literature reviews that show that low-dose
radiation ( LDR ) in whole organisms consistently enhances numerous biological
responses that are highly significant to health (acting opposite to high
dose-rate radiation responses), and demonstrate actions to suppress cancer!
(Clinicians are undertaking applications!)
Technical
Articles
Conference
Papers
Dose-effect
relationship in the immune system after exposure to ionizing radiation
Before the
American Nuclear Society, Washington DC, Nov 2002.
ABSTRACT: It is well known that
immune surveillance is one of the most important defense mechanisms
against cancer and infection. Most carcinogens are immuno-suppressants. So
is ionizing radiation, but only at medium to high doses. The stimulatory
effect of low dose radiation (LDR) on immunity has been studied at
molecular, cellular as well as organism levels. The dose-effect
relationship, in a coordinated manner, of 52 immunologic parameters are
pooled to construct dose-effect curves... These curves have 10~11 doses
between 0 to 10 Gy. To construct such ³complete² curves, we must choose
3~4 dose points in each section of 0.01~0.1 Gy, 0.1~1.0 Gy and 1.0~10.0 Gy.
Many studies neglect doses below 0.2 Gy, thus the LDR effect is missed. It
is shown that omitting data at doses between 0.025 and 0.2 Gy, gives rise
to quadratic curves instead of the J- or inverted J-shaped curves.
Presentations
Non-Linear Dose-Effect Relationship in Radiation Immunology
(PowerPoint slide presentation
converted for the Web)
Amherst, MA,
June 2002.
Dose-effect relationship is one of the most important features in radiobiology studies. In view of the diversity of biological phenomena it is difficult to formulate a universal does-effect model. For doses above 0.5 Gy one can usually construct a linear or linear-quadratic curve. When doses go down to below 0.1~0.2 Gy, the situation may be different due to the distinct biological effects in the low dose region. Thus other models such as J or inverted J curves are usually observed.
Correspondence |
