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RSH > Author Index > Mitchel |
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Radiation, Science, and Health Author Index to Papers and Documents Dr. R. E.
J. Mitchel Science Papers |
Science Papers Radiation Protection in the World of Modern Radiobiology: Time for A New Approach, 2000, by R. E. J. Mitchel, Ph.D. and D. R Boreham, Ph.D., Radiation Biology and Health Physics Branch, AECL, Chalk River Laboratories, Chalk River, ON Canada, at IRPA-10, May 2000, Hiroshima, JAPAN. "None of the predictions of the LNT hypothesis, as it applies to cancer risk from low or chronic doses of low LET radiation, are supported by the data in human or rodent cells. The limited data in animals also indicates that the observed responses are not consistent with the hypothesis. The protective responses observed in mammalian cells and in animals are consistent with those seen in lower eukaryotes, including yeast, indicating that they are evolutionarily conserved and lending credence to the idea that such responses are the normal and expected consequences of low dose exposures. " Scientific advancement depends upon the testing of hypotheses. When the data do not support the hypothesis being tested, that hypothesis must be rejected and replaced with a new testable hypothesis. Since, at low doses and dose rates, there are no data in the literature that support the LNT hypothesis for cancer risk, and considerable evidence contradicting it, including the evidence given above, then this hypothesis must therefore be rejected. "It is time for a new risk based approach to radiation protection, firmly linked to the actual biological responses."
Radiation Biology of Low
Doses,
2001, by
R. E. J. Mitchel, Ph.D.,
Radiation Biology and Health Physics Laboratories,
Chalk River ON, Presented in Munich,
November 29, 2001.
mitchelr@aecl.ca |
RSH > Author Index > Mitchel
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06/14/06
