Revision 1
March 19, 1998

by Radiation, Science, and Health, Inc.,
Edited by J. Muckerheide

1.3
Animal & Plant Biology

1.3.1
Mammals

References
 

"In mice, rats, dogs, swine, and other laboratory animals, a variety of lymphoid and myeloid leukemias have been induced by irradiation (UNSCEAR 1977, UNSCEAR 1986, NRC 1980). In such animals, the dose-incidence relationship has been observed to vary from one type of leukemia to another, but in no instance does it conform to a simple, linear nonthreshold function. The most extensively studied of the experimental leukemias are T-cell neoplasms that arise in the mouse thymus. The induction of these growths is inhibited drastically by shielding a portion of the hemopoietic marrow (UNSCEAR 1977) and may involve the activation of a latent leukemia virus (Rad LV) (Yokoro 1986). The dose-incidence curve for the disease is of the threshold type in mice of certain strains (UNSCEAR 1986)."